The19G11monoclonalantibodyreactswithmouseCD1dalsoknownasCD1.1.CD1disa48kDatypeImembraneglycoproteinandamemberoftheCD1familyofglycoproteins.CD1disanon-classicalMHCproteinwithstructuralhomologytoclassIMHCmolecules.CD1disexpressedonthesurfaceofvariousantigen-presentingcellsandisinvolvedinthepresentationofnon-peptideglycolipidantigenstotoCD1d-restrictedTcells.CD1d-presentedglycolipidantigensactivateinvariantnaturalkillerT(iNKT)cells,throughtheinteractionwiththeT-cellreceptorpresentoniNKTcellmembranes.Whenactivated,iNKTcellsrapidlyproduceTh1andTh2cytokines.
Isotype | RatIgG2b, κ |
RecomendedIsotypeControl(s) | InVivoMAbratIgG2bisotypecontrol,anti-keyholelimpethemocyanin |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
Immunogen | MouseCD1d |
ReportedApplications | invivoCD1dneutralization |
Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Undilutedat4°Cinthedark |
RRID | AB_1107568 |