TheHMN4-14monoclonalantibodyreactswithmouseneurogeniclocusnotchhomolog4(Notch4)amemberoftheNotchfamilyoftype1transmembraneproteins.TheNotchsignalingpathwayisahighlyconservedintercellularsignalingpathway.FiveNotchligandshavebeenidentifiedincludingDLL4andJagged2.UponligandbindingtheNotchreceptorundergoesproteolysisandtranslocatestothenucleusultimatelyactivatingtranscription.TheNotchpathwayhasbeenshowntoplayaroleinmyeloidcellproliferation,hematopoiesis,andembryonicendothelialdevelopment.
Isotype | ArmenianHamsterIgG, κ |
RecomendedIsotypeControl(s) | InVivoMAbpolyclonalArmenianhamsterIgG |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
Immunogen | Notch4-Fcrecombinantprotein |
ReportedApplications |
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Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Undilutedat4°Cinthedark |