About InVivoPlus anti-mouse IL-10R (CD210)
The 1B1.3A monoclonal antibody reacts with mouse IL-10R (IL-10 receptor) also known as CD210. The IL-10R is a class II cytokine receptor and is expressed by a variety of cell types including thymocytes, T lymphocytes, B lymphocytes, NK cells, monocytes, and macrophages. Upon binding IL-10, IL-10R stimulation results in many pleiotropic, effects in immunoregulation and inflammation. IL-10R downregulates the expression of pro-inflammatory cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B lymphocyte survival, proliferation, and antibody production. IL-10R signaling can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. The 1B1.3A antibody is a neutralizing antibody and has been shown to block the binding of human IL-10, which cross-reacts with the mouse IL-10R. However, this clone does not recognize the human IL-10R.
InVivoPlus anti-mouse IL-10R (CD210) Specifications
| Isotype | Rat IgG1, κ |
| Recommended Isotype Control(s) | InVivoPlus rat IgG1 isotype control, anti-horseradish peroxidase(BP0088) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 6.5T Dilution Buffer(IPT065) |
| Immunogen | Recombinant ligand-binding domain of mouse IL-10R |
| Reported Applications |
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| Endotoxin |
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| Binding Validation | Determined by immunoblot |
| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Molecular Weight | 150 kDa |
| Murine Pathogen Test Results |
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| RRID | AB_1107611 |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
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