TheDATK32monoclonalantibodyreactswithmouseLPAM-1alsoknownasintegrinalpha4beta7.The130kDaintegrinβ7chainassociateswiththe150kDaintegrinα4(CD49d)chaintoformLPAM-1,amemberoftheIgsuperfamily.LPAM-1isexpressedbyperipherallymphocytes,smallsubsetsofthymocytes,andbonemarrowProgenitors.LPAM-1bindsVCAM-1(CD106),MAdCAM-1,andfibronectinandfacilitateslymphocyteadhesionandmigrationtotheintestineandassociatedlymphoidtissues.TheDATK32antibodyhasbeenreportedtoblockLPAM-1-mediatedcelladhesioninvivo.
Isotype | RatIgG2a, κ |
RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
Immunogen | TK1cells |
ReportedApplications |
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Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
RRID | AB_1107713 |