TheFD441.8monoclonalantibodyreactswithmouseLFA-1α(lymphocytefunction-associatedantigen1alpha)alsoknownasintegrinalphaLchainandCD11a.LFA-1αandCD18combinetoformLFA-1,a180kDaglycoproteinandamemberoftheintegrinfamily.LFA-1isexpressedonthesurfaceofallleukocytesincludinglymphocytes,monocytes,macrophages,andgranulocytes.LFA-1playsacentralroleinleukocyteintercellularadhesionthroughinteractionswithitsligands,ICAM-1(CD54),ICAM-2(CD102),andICAM-3(CD50),andalsofunctionsinlymphocytecostimulatorysignaling.
Isotype | RatIgG2b |
RecommendedIsotypeControl(s) | InVivoMAbratIgG2bisotypecontrol,anti-keyholelimpethemocyanin(BE0090) |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
Immunogen | ClonedCTLB18cells |
ReportedApplications | invivoLFA-1neutralization |
Endotoxin |
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Purity |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
RRID | AB_1107574 |