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BioXcell/InVivoMAb anti-mouse TIGIT/REGULAR: 50MG/BE0274-R050mg

BioXcell/InVivoMAb anti-mouse TIGIT/REGULAR: 50MG/BE0274-R050mg
  • BioXcell/InVivoMAb anti-mouse TIGIT/REGULAR: 50MG/BE0274-R050mg
商品介绍

About InVivoMAb anti-mouse TIGIT

The 1G9 monoclonal antibody reacts with mouse TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a 26 kDa, type I transmembrane protein and a member of the poliovirus receptor (PVR) family. TIGIT has been found to be expressed on follicular T helper cells in mice while in humans it"s expressed by many T cell subsets including activated T cells, follicular T helper cells, memory T cells, and regulatory T cells as well as on NK cells. TIGIT can interact with certain members of the PVR and PVR-like families, including PVR, PVRL2, PVRL3, CD155, and CD112. TIGIT is thought to negatively regulate NK and T cell activation. Binding of TIGIT on T cells by dendritic cells results in their differentiation into a tolerogenic phenotype, with increased secretion of IL-10 and diminished production of IL-12. TIGIT knock-out mice are more susceptible to autoimmune disease.

InVivoMAb anti-mouse TIGIT Specifications

Isotype

Mouse IgG1, κ

Recommended Isotype Control(s)InVivoMAb mouse IgG1 isotype control, unknown specificity(BE0083)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Mouse TIGIT

Reported Applications
  • in vivo TIGIT blockade
  • in vitro TIGIT blockade
  • Flow cytometry
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein G

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

RRID

AB_2687797

Molecular Weight

150 kDa

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