BioXcell/InVivoPlus anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β/BP0057,BioXcell,,BioXcell,BioXcell inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：BioXcell/InVivoPlus anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β/BP0057

产品编号：BP0057

市场价：¥0.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： BioXcell

公司：BioXcell

公司分类：

商品介绍

AboutInVivoPlusanti-mouse/human/rat/monkey/hamster/canine/bovineTGF-β

The1D11.16.8monoclonalantibodyreactswithmouse,human,rat,monkey,hamster,canineandbovineTGF-β(transforminggrowthfactorbeta)isoforms1,2and3.TGF-βisamultifunctionalcytokinethatregulatestheproliferationofepithelialcells,endothelialcells,fibroblasts,neurons,lymphoidcellsincludingTlymphocytesandNKcells,andotherhematopoieticcelltypes.TGF-βalsoregulatestheactivitiesofactivatedmacrophagesandthedevelopmentofregulatoryTcells.Additionally,TGF-βplaysrolesinimmunefunction,tissueremodelingandwoundrepair.TGF-βexistsasfivehighlysimilarisoforms(TGF-β1-5)withhomologiesof70-80%.TGF-β1issynthesizedbytheenzymaticcleavageofalongprecursorTGF-β1polypeptideencodedbytheTGFB1genewhichyieldsthematureproteinandtheLatencyAssociatedPeptide(LAP).TheLAPandmatureTGF-β1non-covalentlyassociateduringsecretion.TGF-βisubiquitouslyexpressedbymanycelltypesincludingmacrophagesandplateletswhichexpresshighlevelsofTGF-β.TGF-βsignalinghasbeenshowntoplaysrolesincancer,autoimmunediseases,asthma,heartdisease,anddiabetes.ItsimportanceisillustratedbyTGF-βknockoutmicewhichshowdefectsinhematopoiesisandendothelialdifferentiation,anddieofoverwhelminginflammation.The1D11.16.8monoclonalantibodyisaneutralizingantibody.

InVivoPlusanti-mouse/human/rat/monkey/hamster/canine/bovineTGF-βSpecifications

Isotype	MouseIgG1, κ
RecommendedIsotypeControl(s)	InVivoPlusmouseIgG1isotypecontrol,unknownspecificity(BP0083)
RecommendedInVivoPureDilutionBuffer	InVivoPurepH7.0DilutionBuffer(IP0070)
Immunogen	BovineTGFβisoform2
ReportedApplications	invivoTGFβneutralization invitroTGFβneutralization Westernblot
Endotoxin	<1EU/mg(<0.001EU/μg) DeterminedbyLALgelclottingassay
BindingValidation	Determinedbyimmunoblot
Purity	>95% DeterminedbySDS-PAGE
Aggregation	<5% DeterminedbyDLS
Formulation	PBS,pH7.0 ContainsnostABIlizersorpreservatives
Sterility	0.2μMfiltered
Production	Purifiedfromtissueculturesupernatantinananimalfreefacility
Purification	ProteinG
Storage	Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze.
MurinePathogenTestResults	MouseNorovirus:Negative MouseParvovirus:Negative MouseMinuteVirus:Negative MouseHepatitisVirus:Negative ReovirusScreen:Negative LymphocyticChoriomeningitisvirus:Negative LactateDehydrogenase-ElevatingVirus:Negative MouseRotavirus:Negative Theiler"sMurineEncephalomyelitis:Negative Ectromelia/MousepoxVirus:Negative Hantavirus:Negative PolyomaVirus:Negative MouseAdenovirus:Negative SendaiVirus:Negative MycoplasmaPulmonis:Negative PneumoniaVirusofMice:Negative MouseCytomegalovirus:Negative KVirus:Negative
RRID	AB_1107757