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BioXcell/InVivoPlus anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β/BP0057

BioXcell/InVivoPlus anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β/BP0057
  • BioXcell/InVivoPlus anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β/BP0057
商品介绍

AboutInVivoPlusanti-mouse/human/rat/monkey/hamster/canine/bovineTGF-β

The1D11.16.8monoclonalantibodyreactswithmouse,human,rat,monkey,hamster,canineandbovineTGF-β(transforminggrowthfactorbeta)isoforms1,2and3.TGF-βisamultifunctionalcytokinethatregulatestheproliferationofepithelialcells,endothelialcells,fibroblasts,neurons,lymphoidcellsincludingTlymphocytesandNKcells,andotherhematopoieticcelltypes.TGF-βalsoregulatestheactivitiesofactivatedmacrophagesandthedevelopmentofregulatoryTcells.Additionally,TGF-βplaysrolesinimmunefunction,tissueremodelingandwoundrepair.TGF-βexistsasfivehighlysimilarisoforms(TGF-β1-5)withhomologiesof70-80%.TGF-β1issynthesizedbytheenzymaticcleavageofalongprecursorTGF-β1polypeptideencodedbytheTGFB1genewhichyieldsthematureproteinandtheLatencyAssociatedPeptide(LAP).TheLAPandmatureTGF-β1non-covalentlyassociateduringsecretion.TGF-βisubiquitouslyexpressedbymanycelltypesincludingmacrophagesandplateletswhichexpresshighlevelsofTGF-β.TGF-βsignalinghasbeenshowntoplaysrolesincancer,autoimmunediseases,asthma,heartdisease,anddiabetes.ItsimportanceisillustratedbyTGF-βknockoutmicewhichshowdefectsinhematopoiesisandendothelialdifferentiation,anddieofoverwhelminginflammation.The1D11.16.8monoclonalantibodyisaneutralizingantibody.

InVivoPlusanti-mouse/human/rat/monkey/hamster/canine/bovineTGF-βSpecifications

Isotype

MouseIgG1, κ

RecommendedIsotypeControl(s)InVivoPlusmouseIgG1isotypecontrol,unknownspecificity(BP0083)
RecommendedInVivoPureDilutionBufferInVivoPurepH7.0DilutionBuffer(IP0070)
Immunogen

BovineTGFβisoform2

ReportedApplications
  • invivoTGFβneutralization
  • invitroTGFβneutralization
  • Westernblot
Endotoxin
  • <1EU/mg(<0.001EU/μg)
  • DeterminedbyLALgelclottingassay
BindingValidation

Determinedbyimmunoblot

Purity
  • >95%
  • DeterminedbySDS-PAGE
Aggregation
  • <5%
  • DeterminedbyDLS
Formulation
  • PBS,pH7.0
  • ContainsnostABIlizersorpreservatives
Sterility

0.2μMfiltered

Production

Purifiedfromtissueculturesupernatantinananimalfreefacility

Purification

ProteinG

Storage

Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze.

MurinePathogenTestResults
  • MouseNorovirus:Negative
  • MouseParvovirus:Negative
  • MouseMinuteVirus:Negative
  • MouseHepatitisVirus:Negative
  • ReovirusScreen:Negative
  • LymphocyticChoriomeningitisvirus:Negative
  • LactateDehydrogenase-ElevatingVirus:Negative
  • MouseRotavirus:Negative
  • Theiler"sMurineEncephalomyelitis:Negative
  • Ectromelia/MousepoxVirus:Negative
  • Hantavirus:Negative
  • PolyomaVirus:Negative
  • MouseAdenovirus:Negative
  • SendaiVirus:Negative
  • MycoplasmaPulmonis:Negative
  • PneumoniaVirusofMice:Negative
  • MouseCytomegalovirus:Negative
  • KVirus:Negative
RRID

AB_1107757

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