TheHMN4-14monoclonalantibodyreactswithmouseneurogeniclocusnotchhomolog4(Notch4)amemberoftheNotchfamilyoftype1transmembraneproteins.TheNotchsignalingpathwayisahighlyconservedintercellularsignalingpathway.FiveNotchligandshavebeenidentifiedincludingDLL4andJagged2.UponligandbindingtheNotchreceptorundergoesproteolysisandtranslocatestothenucleusultimatelyactivatingtranscription.TheNotchpathwayhasbeenshowntoplayaroleinmyeloidcellproliferation,hematopoiesis,andembryonicendothelialdevelopment.
| Isotype | ArmenianHamsterIgG, κ |
| RecomendedIsotypeControl(s) | InVivoMAbpolyclonalArmenianhamsterIgG |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | Notch4-Fcrecombinantprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |



