ThePK136monoclonalantibodyreactswithmouseNK1.1alsoknownasCD161b/CD161c,KLRB1,NKR-P1AandLy-55.NK1.1isatypeIIintegralmembraneglycoproteinwithaC-typelectindomainandisencodedbytheKlrb1c/NKR-P1Cgene.NK1.1playsrolesinNKcellactivationanddifferentiation,IFN-γproduction,cytotoxicgranulerelease,andisthoughttobeinvolvedinthegenerationofTh2cells.NK1.1ispredominantlyexpressedasadisulfide-linkedhomodimeronNKcellshowever,itisalsoexpressedonNK-Tcells,ararepopulationofTlymphocytes.NK1.1isonlyexpressedbyC57BL/6,FVB/N,andNZBstrainsofmiceandnotAKR,BALB/c,CBA/J,C3H,DBA/1,DBA/2,NOD,SJL,and129strains.
| Isotype | MouseIgG2a, κ |
| RecomendedIsotypeControl(s) | InVivoPlusmouseIgG2aisotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | MousespleenandbonemarrowcellsenrichedforNK1+cells |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinA |
| Storage | Undilutedat4°Cinthedark |
| MurinePathogenTestResults |
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