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来源：BioXcell2020-1-17 访问量：3014评论(0)A major ligand for the inhibitory receptor LAG-3 has been identified and its blockade can potentiate anti-tumor T cell responses Lymphocyte-activation gene 3 (LAG-3) is a receptor that negatively regulates the proliferation, activation, and effector function of T cells. Currently, monoclonal antibodies that block the interaction of LAG-3 with its canonical ligand, MHC-II, are being evaluated for their antitumor activity in clinical trials. However, several antibodies that do not block the binding of LAG-3 to MHC-II have been shown to still promote T cell functions. For example, C9B7W, a popular anti-mouse LAG-3 antibody, enhances the proliferation, effector functions and anti-tumor activity of T cells in vitro and in vivo but does not block MHC-II binding. These studies raise the possibility that LAG-3 may bind to an unknown but functionally important ligand. Read more...![](\"https://bucket.mlcdn.com/a/1042/1042606/images/7c47876f0708dc042a557996903a38589023d496.jpeg/f3a07035eccaeb5214eb56b13859da0560ba6f83.jpeg\")
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